The Recovery trial transformed the care of COVID patients, and could do the same for other common and important diseases. Two years ago, when it said that dexamethasone could save lives, treatment of COVID patients around the world changed almost overnight. An impromptu discussion between two professors on a London bus, when COVID-19 was so new that no proven treatments were available, led to Recovery (Randomized Evaluation of COVID-19 Therapy) being created. Embracing uncertainties and using the best scientific methods to resolve them, Recovery became a scientific machine which provided the kind of easily-understood answers, and certainty, that could be understood by everyone -- doctors, patients and politicians alike. Jointly led by Oxford Population Health and Nuffield Department of Medicine, it produced three results that would completely reshape COVID care in its first 100 days. This is its story.

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