For more than a decade, Dr. David Fajgenbaum, an immunologist at the University of Pennsylvania, has matched rare-disease patients with drugs that are already in pharmacies for other conditions. It began with himself, as a third-year medical student, when he was diagnosed with a rare disorder that causes the immune system to attack vital organs, and figured out that sirolimus, used to prevent transplant patients from rejecting a new kidney, might keep his disease in check. Now, Every Cure, a nonprofit he helped found in 2022, has received major funding to build a drug-repurposing database and algorithms that patients, doctors and researchers can use to find FDA-approved drugs for untreated diseases.

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